Vår litteratur samling av relevante kliniske studier og forskning.


Abat, F., H. Alfredson, M. Cucchiarini, H. Madry, A. Marmotti, C. Mouton, J. M. Oliveira, H. Pereira, G. M. Peretti, D. Romero-Rodriguez, C. Spang, J. Stephen, C. J. A. van Bergen and L. de Girolamo (2017). "Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach." J Exp Orthop 4(1): 18.

Abat, F., H. Alfredson, M. Cucchiarini, H. Madry, A. Marmotti, C. Mouton, J. M. Oliveira, H. Pereira, G. M. Peretti, C. Spang, J. Stephen, C. J. A. van Bergen and L. de Girolamo (2018). "Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part II: treatment options." J Exp Orthop 5(1): 38.

Centeno, C., J. Markle, E. Dodson, I. Stemper, C. J. Williams, M. Hyzy, T. Ichim and M. Freeman (2017). "Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy." J Transl Med 15(1): 197.

Chambers, M. C. and F. H. Fu (2018). "Editorial Commentary: Adult Stem Cell Potential to Enhance Healing of the Anterior Cruciate Ligament." Arthroscopy 34(1): 341-342.

Chiew, S. K., T. S. Ramasamy and F. Amini (2016). "Effectiveness and relevant factors of platelet-rich plasma treatment in managing plantar fasciitis: A systematic review." J Res Med Sci 21: 38.

Coughlin, R. P., A. Oldweiler, D. T. Mickelson and C. T. Moorman, 3rd (2017). "Adipose-Derived Stem Cell Transplant Technique for Degenerative Joint Disease." Arthrosc Tech 6(5): e1761-e1766.

Dallaudiere, B., L. Pesquer, P. Meyer, A. Silvestre, A. Perozziello, A. Peuchant, M. H. Durieux, P. Loriaut, V. Hummel, P. Boyer, E. Schouman-Claeys and J. M. Serfaty (2014). "Intratendinous injection of platelet-rich plasma under US guidance to treat tendinopathy: a long-term pilot study." J Vasc Interv Radiol 25(5): 717-723.

Deans, V. M., A. Miller and J. Ramos (2012). "A prospective series of patients with chronic Achilles tendinopathy treated with autologous-conditioned plasma injections combined with exercise and therapeutic ultrasonography." J Foot Ankle Surg 51(6): 706-710.

Delanois, R. E., Etcheson, J. I., Sodhi, N., Henn III, R. F., Gwam, C. U., George, N. E., & Mont, M. A. (2018). Biologic therapies for the treatment of knee osteoarthritis. The Journal of arthroplasty.

Elghblawi, E. (2018). "Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering." J Cosmet Dermatol 17(3): 423-430.

Filardo, G., B. Di Matteo, E. Kon, G. Merli and M. Marcacci (2018). "Platelet-rich plasma in tendon-related disorders: results and indications." Knee Surg Sports Traumatol Arthrosc 26(7): 1984-1999.

Fitzpatrick, J., M. Bulsara and M. H. Zheng (2017). "The Effectiveness of Platelet-Rich Plasma in the Treatment of Tendinopathy: A Meta-analysis of Randomized Controlled Clinical Trials." Am J Sports Med 45(1): 226-233.

Fotouhi, A., A. Maleki, S. Dolati, A. Aghebati-Maleki and L. Aghebati-Maleki (2018). "Platelet rich plasma, stromal vascular fraction and autologous conditioned serum in treatment of knee osteoarthritis." Biomed Pharmacother 104: 652-660.

Gosens, T., J. C. Peerbooms, W. van Laar and B. L. den Oudsten (2011). "Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up." Am J Sports Med 39(6): 1200-1208.

Hurley, E. T., Y. Yasui, A. L. Gianakos, D. Seow, Y. Shimozono, G. Kerkhoffs and J. G. Kennedy (2018). "Limited evidence for adipose-derived stem cell therapy on the treatment of osteoarthritis." Knee Surg Sports Traumatol Arthrosc 26(11): 3499-3507.

Jevotovsky, D. S., A. R. Alfonso, T. A. Einhorn and E. S. Chiu (2018). "Osteoarthritis and stem cell therapy in humans: a systematic review." Osteoarthritis Cartilage 26(6): 711-729.

Kaizawa, Y., A. Franklin, J. Leyden, A. W. Behn, U. S. Tulu, D. Sotelo Leon, Z. Wang, G. D. Abrams, J. Chang and P. M. Fox (2019). "Augmentation of chronic rotator cuff healing using adipose-derived stem cell-seeded human tendon-derived hydrogel." J Orthop Res 37(4): 877-886.

Kantrowitz, D. E., A. S. Padaki, C. S. Ahmad and T. S. Lynch (2018). "Defining Platelet-Rich Plasma Usage by Team Physicians in Elite Athletes." Orthop J Sports Med 6(4): 2325967118767077.

Kaur, H., K. Corscadden, C. Lott, H. S. Elbatarny and M. Othman (2016). "Bromelain has paradoxical effects on blood coagulability: a study using thromboelastography." Blood Coagul Fibrinolysis 27(7): 745-752.

Kim, K. D. (2016). "Stem Cells and Discogenic Low Back Pain." Spine (Phila Pa 1976) 41 Suppl 7: S11-12.

Kushchayev, S. V., T. Glushko, M. Jarraya, K. H. Schuleri, M. C. Preul, M. L. Brooks and O. M. Teytelboym (2018). "ABCs of the degenerative spine." Insights Imaging 9(2): 253-274.

Kwapisz, A., S. Prabhakar, R. Compagnoni, A. Sibilska and P. Randelli (2018). "Platelet-Rich Plasma for Elbow Pathologies: a Descriptive Review of Current Literature." Curr Rev Musculoskelet Med 11(4): 598-606.

Laver, L., N. Marom, L. Dnyanesh, O. Mei-Dan, J. Espregueira-Mendes and A. Gobbi (2017). "PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies." Cartilage 8(4): 341-364.

Martinelli, N., A. Marinozzi, S. Carni, U. Trovato, A. Bianchi and V. Denaro (2013). "Platelet-rich plasma injections for chronic plantar fasciitis." Int Orthop 37(5): 839-842.

Michalek, J., R. Moster, L. Lukac, K. Proefrock, M. Petrasovic, J. Rybar, A. Chaloupka, A. Darinskas, J. Michalek, J. Kristek, J. Travnik, P. Jabandziev, M. Cibulka, J. Skopalik, Z. Kristkova and Z. Dudasova (2017). "Stromal Vascular Fraction Cells of Adipose and Connective Tissue in People with Osteoarthritis: A Case Control Prospective Multi-Centric Non-Randomized Study." Global Surgery 3(3).

Michalek, J., A. Vrablikova, A. Darinskas, L. Lukac, J. Prucha, J. Skopalik, J. Travnik, M. Cibulka and Z. Dudasova (2019). "Stromal vascular fraction cell therapy for osteoarthritis in elderly: Multicenter case-control study." J Clin Orthop Trauma 10(1): 76-80.

Monto, R. R. (2012). "Platelet rich plasma treatment for chronic Achilles tendinosis." Foot Ankle Int 33(5): 379-385.

MS, A. H., M. R. Mohamed Ali, A. Yusof, J. George and L. P. Lee (2014). "Platelet-rich plasma injections for the treatment of hamstring injuries: a randomized controlled trial." Am J Sports Med 42(10): 2410-2418.

Murray, D. J., S. Javed, N. Jain, S. Kemp and A. C. Watts (2015). "Platelet-Rich-Plasma Injections in Treating Lateral Epicondylosis: a Review of the Recent Evidence." J Hand Microsurg 7(2): 320-325.

O'Connell, B., N. M. Wragg and S. L. Wilson (2019). "The use of PRP injections in the management of knee osteoarthritis." Cell Tissue Res 376(2): 143-152.

Pas, H. I., M. Winters, H. J. Haisma, M. J. Koenis, J. L. Tol and M. H. Moen (2017). "Stem cell injections in knee osteoarthritis: a systematic review of the literature." Br J Sports Med 51(15): 1125-1133.

Patel, S., A. P. Gualtieri, H. H. Lu and W. N. Levine (2016). "Advances in biologic augmentation for rotator cuff repair." Ann N Y Acad Sci 1383(1): 97-114.

Rha, D. W., G. Y. Park, Y. K. Kim, M. T. Kim and S. C. Lee (2013). "Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial." Clin Rehabil 27(2): 113-122.

Setayesh, K., A. Villarreal, A. Gottschalk, J. M. Tokish and W. S. Choate (2018). "Treatment of Muscle Injuries with Platelet-Rich Plasma: a Review of the Literature." Curr Rev Musculoskelet Med 11(4): 635-642.

Sheth, U., T. Dwyer, I. Smith, D. Wasserstein, J. Theodoropoulos, S. Takhar and J. Chahal (2018). "Does Platelet-Rich Plasma Lead to Earlier Return to Sport When Compared With Conservative Treatment in Acute Muscle Injuries? A Systematic Review and Meta-analysis." Arthroscopy 34(1): 281-288 e281.

Ugurlar, M., M. M. Sonmez, O. Y. Ugurlar, L. Adiyeke, H. Yildirim and O. T. Eren (2018). "Effectiveness of Four Different Treatment Modalities in the Treatment of Chronic Plantar Fasciitis During a 36-Month Follow-Up Period: A Randomized Controlled Trial." J Foot Ankle Surg 57(5): 913-918.

Urits, I., O. Viswanath, A. C. Galasso, E. R. Sottosani, K. M. Mahan, C. M. Aiudi, A. D. Kaye and V. J. Orhurhu (2019). "Platelet-Rich Plasma for the Treatment of Low Back Pain: a Comprehensive Review." Curr Pain Headache Rep 23(7): 52.

von Wehren, L., F. Blanke, A. Todorov, P. Heisterbach, J. Sailer and M. Majewski (2016). "The effect of subacromial injections of autologous conditioned plasma versus cortisone for the treatment of symptomatic partial rotator cuff tears." Knee Surg Sports Traumatol Arthrosc 24(12): 3787-3792.

Wu, T., H. X. Song, Y. Dong and J. H. Li (2018). "Cell-Based Therapies for Lumbar Discogenic Low Back Pain: Systematic Review and Single-Arm Meta-analysis." Spine (Phila Pa 1976) 43(1): 49-57.

Yang, W. Y., Y. H. Han, X. W. Cao, J. K. Pan, L. F. Zeng, J. T. Lin and J. Liu (2017). "Platelet-rich plasma as a treatment for plantar fasciitis: A meta-analysis of randomized controlled trials." Medicine (Baltimore) 96(44): e8475.

Zhou, W., J. Lin, K. Zhao, K. Jin, Q. He, Y. Hu, G. Feng, Y. Cai, C. Xia, H. Liu, W. Shen, X. Hu and H. Ouyang (2019). "Single-Cell Profiles and Clinically Useful Properties of Human Mesenchymal Stem Cells of Adipose and Bone Marrow Origin." Am J Sports Med 47(7): 1722-1733.

Pak J, Lee JH, Kartolo WA, and Lee SH. 2016.
»Cartilage Regeneration in Human with Adipose Tissue-Derived Stem Cells: Current Status in Clinical Implications.«
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736810/

Van Lent P, Schelbergen R, Huurne MT, et al. 2013.
»Synovial Activation in Experimental OA Drives Rapid Suppressive Effects of Adipose-Derived Stem Cells after Local Administration and Protects Against Development of Ligament Damage.«
Ann Rheum Dis. 72 (Suppl 3)

Freitag J, Li D, Wickham J, Shah K, Tenen A. 2017.
»Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee
BMJ Case Rep.

Freitag J, Shah K, Wickham J, Boyd R, Tenen A. 2017.
»The effect of autologous adipose derived mesenchymal stem cell therapy in the treatment of a large osteochondral defect of the knee following unsuccessful surgical intervention of osteochondritis dissecans – a case study
BMC Musculoskelet Disord. 18 (1)

Freitag J, Ford J, Bates D, et al. 2015.
»Adipose derived mesenchymal stem cell therapy in the treatment of isolated knee chondral lesions: Design of a randomised controlled pilot study comparing arthroscopic microfracture versus arthroscopic microfracture combined with postoperative mesenchymal stem cell injections.«
BMJ Open. 5 (12)

Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. 2008.
»Increased Knee Cartilage Volume in Degenerative Joint Disease using Percutaneously Implanted, Autologous Mesenchymal Stem Cells.«

Koh YG, Choi YJ, Kwon SK, Kim YS, Yeo JE. 2015.
»Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis.« Knee Surg Sports Traumatol Arthrosc. 23 (5)

Koh YG et al: Comparative outcomes of open-wedge high tibial osteotomy with platelet-rich plasma alone or in combination with mesenchymal stem cell treatment: a prospective study. Arthroscopy, 2014;30(11):1453-60 - Kne artrose.

Im GI: Regeneration of articular cartilage using adipose stem cells. Journal of Biomedical Materials Research, 2016;104(7):1830-44

Xu FT et al: Effect of activated autologous platelet-rich plasma on proliferation and osteogenic differentiation of human adipose-derived stem cells in vitro Am J Transl Res, 2015;7(2):257-70

Shen J et al: Autologous platelet-rich plasma promotes proliferation and chondrogenic differentiation of adipose-derived stem cells. Molecular Medicine Reports, 2015;11(2):1298-303

Loibl M et al: The effect of leukocyte-reduced platelet-rich plasma on the proliferation of autologous adipose-tissue derived mesenchymal stem cells. Clin Hemorheol Microcirc, 2016;61(4):599-614 stamcellebehandling av kne smerter

Van Pham P et al: Activated platelet-rich plasma improves adipose-derived stem cell transplantation efficiency in injured articular cartilage. Stem Cell av kne smerter Research & Therapy, 2013;4(4):91

Stessuk T et al: Platelet-rich plasma (PRP) and adipose-derived mesenchymal stem cells: stimulatory effects on proliferation and migration of fibroblasts and keratinocytes in vitro. Arch Dermatol Res, 2016;308(7):511-20

Mazzocca A et al: Platelet-rich plasma differs according to preparation method and human variability. Journal of Bone & Joint surgery. stamcellebehandling av kne - 2012;94(4):308-16

Borzini P, Mazzucco L: Tissue regeneration and in loco administration of platelet derivates: clinical outcomes, heterogeneous products, and heterogeneity of effector Mechanisms. Transfusion. 2005;45(11):1759-67

Edwards D et al: Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. The EMBO Journal. 1987;6(7):1899-904

Lynch SE et al: “Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors.” Proc. Natl. Acad. Sci. USA. 1987;84(21):7696-700

Mazzocca A et al: The positive effects of different platelet-rich plasma methods on human muscle, bone, and tendon cells. The American Journal of Sports Medicine. 2012; 40(8):1742-49

Cho J W et al: Platelet-rich plasma induces increased expression of G1 cell cycle regulators, type I collagen, and matrix metalloproteinase-1 in human skin fibroblasts. International Journal of Molecular Medicine. 2012;29(1):32-6

Andia I et al: Basic Science: Molecular and Biological Aspects of Platelet-Rich Plasma Therapies. Operative Techniques in Orthopaedics. 2012;22(1):3-9

Van Dongen JA et al: The fractionation of adipose tissue procedure to obtain stromal vascular fractions for regenerative purposes. Wound Repair and Regeneration, 2016;24(6):994-1003

Kasir R, Vernekar VN, Laurencin CT: Regenerative Engineering of Cartilage using Adipose-Derived Stem Cells. Regen Eng Transl Med, 2015;1(1):42-49

Shukla et al: Adipose-derived stem cells in radiotherapy injury: a new frontier. Frontiers in Surgery, 2015;2(1):1-12

Nguyen et al: Comparative Clinical Observation of Arthroscopic Microfracture in the Presence and Absence of a Stromal Vascular Fraction Injection for Osteoarthritis. Stem Cells Trans Med, 2016;5:1-9

Konrad Słynarski et al: Treatment of Osteoarthritis: Adipose Derived Stem Cell and PRP Therapy. Sportärztezeitung. 2017;3:14-18